The dead cells that have to be removed from your skin's layers. As skin tissues die and get regenerated, the old and dead cells are removed by the oily sebum produced by the sebaceous glands. Dead skin cells in excessive quantities will block your skin's pores.
Sebaceous glands
The factories underneath your skin which produce facial oil to moisturize dry skin and remove dead skin cells. If your glands are sensitive, excessive sebum gets produced and can clog your pores.
Facial sebum
The oily substance that is produced by sebaceous glands to moisturize your skin and push dead skin cells to the surface of your skin. Excessive facial sebum production will contribute to pore blockage. The amount of sebum produced by your skin is determined by the sensitivity of the sebaceous glands and the amount of hormone testosterone produced by your body's hormonal system.
Hormonal Imbalance
Excessive hormone production can lead to increased production of facial oil or sebum.
Clogged Pores - The Tipping Point!
Clogged pores almost always means the start of acne. Pores get blocked when the sticky mixture (made from sebum, dead skin cells and dirt) is formed in the pore.
This sticky mixture blocks the opening of the pore and makes it impossible for it to get disposed. When this oily, sticky mixture gets formed in the pore, the acne-causing bacteria which is friendly and harmless by the way, feasts on it. The bacteria consume the fats and releases some toxic dump.
When the immune cells finds out about this, they get overstimulated and over-reacted. They start spilling biohazard chemicals all over the "infected" area and create excessive damage! This is when your skin gets the bumps. A good immune system will definitely help you overcome acne.